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JNU-0921

CAT: 0931-T89884-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T89884-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
TNF
Related Pathways
Apoptosis
Bioactivity
JNU-0921, as a CD137 activator, exhibits highly efficient oral activity. It enhances the mRNA expression of IFN-γ and GZMB and induces luciferase activity with an EC50 of 64.07 nM. JNU-0921 also boosts both the efficacy and memory function of cytotoxic CD8+ T cells (CTL), alleviating their exhaustion. Moreover, it promotes the polarization of helper T cells towards a Type 1 helper profile, thereby augmenting their activity to enhance CTL function. Additionally, JNU-0921 possesses anticancer properties.
Molecular Formula
C19H12N2O3
Molecular Weight
316.31
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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