JNU-0921

• Target:

  TNF

• Related Pathways:

  Apoptosis

• Bioactivity:

  JNU-0921, as a CD137 activator, exhibits highly efficient oral activity. It enhances the mRNA expression of IFN-? and GZMB and induces luciferase activity with an EC50 of 64.07 nM. JNU-0921 also boosts both the efficacy and memory function of cytotoxic CD8+ T cells (CTL), alleviating their exhaustion. Moreover, it promotes the polarization of helper T cells towards a Type 1 helper profile, thereby augmenting their activity to enhance CTL function. Additionally, JNU-0921 possesses anticancer properties.

• Molecular Formula:

  C19H12N2O3

• Molecular Weight:

  316.31

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C