Dios-Arg (diTFA)

• Description:

  Dios-Arg diTFA, a cationic lipid with an arginine-bearing headgroup, shows obvious double bond proton signals at around 5.2-5.3 ppm. Dios-Arg diTFA is used, coupled to DOPE, to bind siRNA and plasmid to for cationic LNPs for intracellular transport[1][2].

• UNSPSC:

  12352200

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Liposome

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/dios-arg-ditfa.html

• Solubility:

  10 mM in DMSO

• Smiles:

  [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC=C6C[C@@H](OC(CCCCCNC([C@@H](N)CCCNC(N)=N)=O)=O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H].O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

• Molecular Formula:

  C43H67F6N5O9

• Molecular Weight:

  912.01

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Ruilong Sheng, et al. Cationic Nanoparticles Assembled from Natural-Based Steroid Lipid for Improved Intracellular Transport of siRNA and pDNA. Nanomaterials (Basel) . 2016 Apr 13;6 (4) :69.|[2]Ruilong Sheng, et al. Skeleton-Controlled pDNA Delivery of Renewable Steroid-Based Cationic Lipids, the Endocytosis Pathway Analysis and Intracellular Localization. Int J Mol Sci. 2018 Jan 26;19 (2) :369.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Biochemical Assay Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  1807353-31-6