BIBO3304 (diTFA)

CAT: 0804-HY-107725ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107725ASize:1 Each
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Description
BIBO3304 (diTFA) is an orally effective and selective neuropeptide Y (NPY) Y1 receptor antagonist. BIBO3304 (diTFA) has a high affinity for both human and rat Y1 receptors, with IC50 values of 0.38 and 0.72 nM, respectively. BIBO3304 (diTFA) promotes bone-tendon healing through the Wnt/β-catenin signaling pathway[1][2][3].
CAS Number
[2310085-85-7]
UNSPSC
12352005
Target
Neuropeptide Y Receptor; Wnt
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling; Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/bibo3304-ditfa.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@@H](C(NCC1=CC=C(CNC(N)=O)C=C1)=O)CCCNC(N)=N)C(C2=CC=CC=C2)C3=CC=CC=C3.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F
Molecular Formula
C33H37F6N7O7
Molecular Weight
757.68
References & Citations
[1]Wieland HA, et al. Subtype selectivity of the novel nonpeptide neuropeptide Y Y1 receptor antagonist BIBO 3304 and its effect on feeding in rodents. Br J Pharmacol. 1998 Oct;125 (3) :549-55.|[2]Chen Y, et al. Early treadmill running delays rotator cuff healing via Neuropeptide Y mediated inactivation of the Wnt/β-catenin signaling. J Orthop Translat. 2021 Oct 11;30:103-111.|[3]Loh K, et al. Inhibition of Y1 receptor signaling improves islet transplant outcome. Nat Commun. 2017 Sep 8;8 (1) :490.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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