Nemifitide (diTFA)

CAT: 0804-HY-105077A-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-105077A-01Size:5 mg

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Description

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) [2]. Nemifitide diTFA can cross the blood-brain barrier[3].

CAS Number

204992-09-6

Product Name Alternative

INN 00835 (diTFA)

UNSPSC

12352209

Target

5-HT Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/nemifitide-ditfa.html

Purity

98.24

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

FC(C=C1)=CC=C1C[C@H](N)C(N2[C@@H](C[C@@H](O)C2)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)=O)=O.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Molecular Formula

C37H45F7N10O10

Molecular Weight

922.80

References & Citations

[1]Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55 (2-3) :231-5.|[2]Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl) . 2004 Sep;175 (3) :303-9.|[3]Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9 (5) :517-28.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

Phase 2

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Nemifitide (diTFA)

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