Spexin (TFA)

• Description :

  Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents) . Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142) -induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3].

• Product Name Alternative :

  Neuropeptide Q (TFA)

• UNSPSC :

  12352209

• Target :

  Apoptosis; Autophagy; Ferroptosis; Neuropeptide Y Receptor

• Type :

  Peptides

• Related Pathways :

  Apoptosis; Autophagy; GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Metabolic Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/spexin-tfa.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC(C(F)(F)F)=O.O=C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@@H](CC(C)C)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(NCC(N[C@@H](C)C(N[C@H](C(N)=O)CCC(N)=O)=O)=O)=O)=O)=O)CC2=CC=C(C=C2)O)=O)=O)=O)=O)=O)[C@H]([C@H](O)C)NC([C@@H](NC([C@@H](N)CC(N)=O)=O)CC3=CNC4=CC=CC=C34)=O

• Molecular Formula :

  C74H114N20O19S.xC2HF3O2

• Molecular Weight :

  1619.88 (free base)

• References & Citations :

  [1]Porzionato A, et al. Spexin expression in normal rat tissues. J Histochem Cytochem. 2010;58 (9) :825-837.|[2]Ou W, et al. Spexin inhibits excessive autophagy-induced ferroptosis to alleviate doxorubicin-induced cardiotoxicity by upregulating Beclin 1. Br J Pharmacol. 2024 Nov;181 (21) :4195-4213.|[3]Walewski JL, et al. Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity. Obesity (Silver Spring) . 2014 Jul;22 (7) :1643-52.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported