AChE-IN-85

• Description:

  AChE-IN-85 (Compound 7k) is an AChE inhibitor with an IC50 of 0.083 μM. AChE-IN-85 can inhibit the release of NO, the production of TNF-α and IL-1β, the levels of LDH and ROS, as well as the aggregation of Aβ42. AChE-IN-85 has anti-inflammatory and neuroprotective effects and can be used in the research of diseases such as Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Cholinesterase (ChE) ; Interleukin Related; Lactate Dehydrogenase; Reactive Oxygen Species (ROS)

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  O=C(NC1=NC2=CC=C(Cl)C=C2S1)CN3N=NC(CN(C/4=O)C(SC4=C/C5=CC=C(F)C=C5)=O)=C3

• Molecular Formula:

  C22H14ClFN6O3S2

• Molecular Weight:

  528.97

• References & Citations:

  [1]Almatary AM, et al. "Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors". Bioorg Chem. 2025 Apr;157:108295.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; IL-1