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AChE-IN-85

CAT: 0804-HY-173144Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173144Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AChE-IN-85 (Compound 7k) is an AChE inhibitor with an IC50 of 0.083 μM. AChE-IN-85 can inhibit the release of NO, the production of TNF-α and IL-1β, the levels of LDH and ROS, as well as the aggregation of Aβ42. AChE-IN-85 has anti-inflammatory and neuroprotective effects and can be used in the research of diseases such as Alzheimer's disease[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Interleukin Related; Lactate Dehydrogenase; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(NC1=NC2=CC=C(Cl)C=C2S1)CN3N=NC(CN(C/4=O)C(SC4=C/C5=CC=C(F)C=C5)=O)=C3
Molecular Formula
C22H14ClFN6O3S2
Molecular Weight
528.97
References & Citations
[1]Almatary AM, et al. "Triazole-linked thiazolidinedione-Benzothiazole hybrids: Design and biological evaluation as AChE inhibitors". Bioorg Chem. 2025 Apr;157:108295.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; IL-1

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