AS-85
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No


AS-85
Description:
AS-85 is a potent ASH1L histone methyltransferase inhibitor (IC50=0.6 μM) with anti-leukemic activity. AS-85 strongly binds to the ASH1L SET domain, with the Kd value of 0.78 μM[1].UNSPSC:
12352005Target:
Histone MethyltransferaseType:
Reference compoundRelated Pathways:
EpigeneticsApplications:
Cancer-programmed cell deathField of Research:
CancerAssay Protocol:
https://www.medchemexpress.com/as-85.htmlPurity:
98.40Solubility:
DMSO : 100 mg/mL (ultrasonic)Smiles:
O=C(C1CNC1)NCC2=CC3=C(C=C2)C(C4=CC=CC(C(N)=S)=C4)=CN3C5CCN(S(=O)(C(F)(F)F)=O)CC5Molecular Formula:
C26H28F3N5O3S2Molecular Weight:
579.66References & Citations:
[1]David S. Rogawski, Jing Deng, Hao Li, Tomasz Cierpicki, Jolanta Grembecka, et al. Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nat Commun. 2021 May 14;12 (1) :2792.Shipping Conditions:
Blue IceStorage Conditions:
-20°C (Powder, sealed storage, away from moisture and light)Scientific Category:
Reference compound1Clinical Information:
No Development ReportedIsoform:
ASH1L/KMT2HCAS Number:
[2323623-80-7]
