AChE-IN-80

• Description:

  AChE-IN-80 (Compound 1) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-80 can inhibit inflammation and the production of reactive oxygen species (ROS) in vitro- cultured neurons and microglia, trigger autophagy responses, and block the propagation of β-amyloid (Aβ) fibrils. AChE-IN-80 possesses antioxidant activity and neuroprotective effects and can be used in the study of Alzheimer's disease[1].

• UNSPSC:

  12352005

• Target:

  Amyloid-β; Autophagy; Reactive Oxygen Species (ROS)

• Related Pathways:

  Autophagy; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  NC(C1=CC(OC(N(C)CC)=O)=CC=C1)=S

• Molecular Formula:

  C11H14N2O2S

• Molecular Weight:

  238.31

• References & Citations:

  [1]Sestito S, et al. Design, synthesis and biological evaluation of new H2S-releasing rivastigmine derivatives as neuroprotective molecules[J]. European Journal of Medicinal Chemistry, 2025, 283: 117175.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported