D18

CAT: 0804-HY-144501-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144501-01Size:1 mg
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Description
D18 is an immune modulator. D18 acts as a TLR7/8 dual agonist (EC50 = 24 nM for hTLR7 and 10 nM for hTLR8, respectively) . D18 increases PD-L1 expression through epigenetic regulation, thus sensitizing tumors to PD-1/PD-L1 blockade. D18 is a ADC cytotoxin uesd for the systhesis of ADC HE-S2 (HY-144497) . D18 has strong immune activation and anti-tumor activity. D18 commonly used in cancer research, such as colon cancer[1][2].
CAS Number
[2230218-36-5]
UNSPSC
12352005
Target
PD-1/PD-L1; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/d18.html
Purity
98.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
NC(N=C1NCCCC)=NC(C1=N2)=CC=C2CC(C=C3)=CC=C3CN(C)C
Molecular Formula
C21H28N6
Molecular Weight
364.49
References & Citations
[1]He L, et al. Immune Modulating Antibody-Drug Conjugate (IM-ADC) for Cancer Immunotherapy. J Med Chem. 2021;64 (21) :15716-15726. |[2]Wang Z, et al. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy. J Med Chem. 2021 Jun 10;64 (11) :7507-7532.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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