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BuChE-IN-20

CAT: 0804-HY-172782Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172782Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BuChE-IN-20 is a selective butyrylcholinesterase (hBuChE) inhibitor (IC50 = 0.13 μM) with BBB permeability. BuChE-IN-20 is a L-Tryptophan derivative. BuChE-IN-20 possesses neuroprotective properties by inhibiting the production of nitric oxide (NO) and lowering the levels of ROS. BuChE-IN-20 is proficient in inhibiting the self-aggregation of amyloid-beta (Aβ) peptides. BuChE-IN-20 can be used in research for Alzheimer’s disease[1].
UNSPSC
12352005
Target
Amyloid-β; Cholinesterase (ChE) ; Interleukin Related; NOD-like Receptor (NLR) ; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB
Applications
Neuroscience-Neurodegeneration
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
OC1=C(F)C=C(CN[C@@H](CC2=CNC3=CC=CC=C32)C(N(C)CCC4=CNC5=C4C=CC=C5)=O)C=C1
Molecular Formula
C29H29FN4O2
Molecular Weight
484.56
References & Citations
[1]Atlante S, et al., A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties. Aging Cell. 2025 Mar 17:e70047.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BChE

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