LZ-007

• Target:

  FXR

• Related Pathways:

  Metabolism

• Bioactivity:

  LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.

• Smiles:

  O=C(O)C1=CC=C(OCC2CCN(CC=3C(=NOC3C(C)C)C=4C=CC=CC4OC(F)(F)F)CC2)C=C1

• Molecular Formula:

  C27H29F3N2O5

• Molecular Weight:

  518.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2920000-23-1