LZ-007

CAT: 0931-T203062-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T203062-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2920000-23-1

Target

FXR

Related Pathways

Metabolism

Bioactivity

LZ-007 is an agonist of the Farnesoid X receptor (FXR), with an EC50 of 51 nM as determined by TR-FRET assay, and an EC50 of 76 nM in HepG2 cells. It exhibits favorable pharmacokinetic properties in SD rats and can improve metabolic dysfunction-associated steatohepatitis induced by high-fat diets and CCl4 in mice.

Smiles

O=C(O)C1=CC=C(OCC2CCN(CC=3C(=NOC3C(C)C)C=4C=CC=CC4OC(F)(F)F)CC2)C=C1

Molecular Formula

C27H29F3N2O5

Molecular Weight

518.53

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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LZ-007

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