P7–2302

• Description:

  P7-2302 inhibits PDE7 and PDE4B with IC50 of 0.18 nM and 77.3 nM. P7-2302 inhibits the efflux of P-gp and BCRP (breast cancer resistance protein), exhibits low uptake in rats brain. P7-2302 can be used as a PET tracer when labeled with 18F[1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(N1CC(F)C1)C2=C(OC3=C4C(NC(OC45CCCCC5)=O)=C(Cl)C=C3)C(F)=CC=C2

• Molecular Formula:

  C23H21ClF2N2O4

• Molecular Weight:

  462.87

• References & Citations:

  [1]Rong J, et al. Development of a Novel 18F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography. Mol Pharm. 2025 Mar 3;22 (3) :1657-1666.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE4; PDE7