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P7–2302

CAT: 0804-HY-172365Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172365Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
P7-2302 inhibits PDE7 and PDE4B with IC50 of 0.18 nM and 77.3 nM. P7-2302 inhibits the efflux of P-gp and BCRP (breast cancer resistance protein), exhibits low uptake in rats brain. P7-2302 can be used as a PET tracer when labeled with 18F[1].
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
O=C(N1CC(F)C1)C2=C(OC3=C4C(NC(OC45CCCCC5)=O)=C(Cl)C=C3)C(F)=CC=C2
Molecular Formula
C23H21ClF2N2O4
Molecular Weight
462.87
References & Citations
[1]Rong J, et al. Development of a Novel 18F-Labeled Radioligand for Imaging Phosphodiesterase 7 with Positron Emission Tomography. Mol Pharm. 2025 Mar 3;22 (3) :1657-1666.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4; PDE7

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