DTX-P7

• Description :

  DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90[1].

• UNSPSC :

  12352209

• Target :

  Apoptosis; Eukaryotic Initiation Factor (eIF) ; HSP; Peptide-Drug Conjugates (PDCs) ; PERK

• Type :

  Peptides

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/dtx-p7.html

• Smiles :

  O=C(OC(C)(C)C)N[C@H]([C@@H](OC(CCC(N[C@@H](CC(C)C)C(N1[C@H](C(N[C@H](C(N[C@@H]([C@H](O)C)C(N2CCC[C@H]2C(N[C@@H](CC(C)C)C(N3CCC[C@H]3C(O)=O)=O)=O)=O)=O)CC(C)C)=O)CCC1)=O)=O)=O)C(O[C@@H]4C(C)=C([C@@H](O)C([C@@]5(C)[C@]([C@@](CO6)(OC(C)=O)[C@@]6([H])C[C@@H]5O)([H])[C@@H]7OC(C8=CC=CC=C8)=O)=O)C(C)(C)[C@@]7(O)C4)=O)C9=CC=CC=C9

• Molecular Formula :

  C84H118N8O25

• Molecular Weight :

  1639.87

• References & Citations :

  [1]Yao Jiang, et al. DTX-P7, a peptide-drug conjugate, is highly effective for non-small cell lung cancer. J Hematol Oncol. 2022 Jun 3;15 (1) :73.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported