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CSRC/BCR-ABL-IN-1

CAT: 0804-HY-172096Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172096Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CSRC/BCR-ABL-IN-1 (compound 21b) is a potent Bcr-Abl and C-Src inhibitor with IC50 values of 56.2, 101 nM for Bcr-Abl, C-Src, respectively. cSRC/BCR-ABL-IN-1 shows cytotoxicity activity[1].
UNSPSC
12352005
Target
Bcr-Abl; Src
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
C=CC(N(C1=C(C=NC2=CC(OCCCN3CCN(CC3)C)=C(C=C21)OC)C#N)C4=CC(OC)=C(C=C4Cl)Cl)=O
Molecular Formula
C29H31Cl2N5O4
Molecular Weight
584.49
References & Citations
[1]Lin C, et al. Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity. Bioorg Med Chem Lett. 2025 Jan 13;119:130105.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bcr-Abl

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