ALT-007

• Description:

  ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research[1].

• UNSPSC:

  12352005

• Target:

  Acyltransferase; Ceramidase

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Purity:

  99.81

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C(NC1C(N(C(C)C)N=C2)=C2N(C(C3=CN=C(OC)C(OC)=C3)=O)CC1)C4=CC=CC=C4OC(F)(F)F

• Molecular Formula:

  C25H26F3N5O5

• Molecular Weight:

  533.50

• References & Citations:

  [1]Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8 (1) :203-215.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2035010-37-6]