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ALT-007

CAT: 0804-HY-170794-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-170794-01Size:1 mg
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Description
ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research[1].
CAS Number
2035010-37-6
UNSPSC
12352005
Target
Acyltransferase; Ceramidase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Purity
99.81
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1C(N(C(C)C)N=C2)=C2N(C(C3=CN=C(OC)C(OC)=C3)=O)CC1)C4=CC=CC=C4OC(F)(F)F
Molecular Formula
C25H26F3N5O5
Molecular Weight
533.50
References & Citations
[1]Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8 (1) :203-215.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N-(4-(5,6-Dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide
CAS Number2035010-37-6
PubChem CID134278627
IUPAC NameN-[4-(5,6-dimethoxypyridine-3-carbonyl)-1-propan-2-yl-6,7-dihydro-5H-pyrazolo[4,5-b]pyridin-7-yl]-2-(trifluoromethoxy)benzamide
Molecular FormulaC25H26F3N5O5
Molecular Weight533.5
XLogP3.3
Topological Polar Surface Area108
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count38
Formal Charge0
Complexity834
SMILES
CC(C)N1C2=C(C=N1)N(CCC2NC(=O)C3=CC=CC=C3OC(F)(F)F)C(=O)C4=CC(=C(N=C4)OC)OC
InChI
InChI=1S/C25H26F3N5O5/c1-14(2)33-21-17(31-22(34)16-7-5-6-8-19(16)38-25(26,27)28)9-10-32(18(21)13-30-33)24(35)15-11-20(36-3)23(37-4)29-12-15/h5-8,11-14,17H,9-10H2,1-4H3,(H,31,34)
InChIKey
MOKGQUKWOUYHHS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(4-(5,6-Dimethoxynicotinoyl)-1-isopropyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-b]pyridin-7-yl)-2-(trifluoromethoxy)benzamide
CAS: 2035010-37-6
CID: 134278627
Formula: C25H26F3N5O5
MW: 533.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight533.5
XLogP33.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass533.18860343
Monoisotopic Mass533.18860343
Topological Polar Surface Area108 Ų
Heavy Atom Count38
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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