ALT-007

CAT: 0804-HY-170794-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-170794-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ALT-007 is an orally active serine palmitoyltransferase (SPT) inhibitor that selectively reduces the levels of toxic very-long-chain deoxysphingolipids to enhance protein homeostasis. ALT-007 restores aging-related loss of muscle mass in a mouse model of sarcopenia. ALT-007 enhances protein homeostasis in both mouse and C. elegans models of aging and disease. ALT-007 can be used for age-related neuromuscular diseases research[1].
CAS Number
[2035010-37-6]
UNSPSC
12352005
Target
Acyltransferase; Ceramidase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Purity
99.81
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C(NC1C(N(C(C)C)N=C2)=C2N(C(C3=CN=C(OC)C(OC)=C3)=O)CC1)C4=CC=CC=C4OC(F)(F)F
Molecular Formula
C25H26F3N5O5
Molecular Weight
533.50
References & Citations
[1]Poisson J, et al. Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia. ACS Pharmacol Transl Sci. 2024 Dec 29;8 (1) :203-215.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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