ALT-2074

• Description:

  ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome[1].

• Product Name Alternative:

  BXT-51072

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  Cytochrome P450; Glutathione Peroxidase

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  CC1(C)CN[Se]C2=C1C=CC=C2

• Molecular Formula:

  C10H13NSe

• Molecular Weight:

  226.18

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Greenblatt DJ, et al. Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso- (2H) -selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase. Br J Clin Pharmacol. 2009 Dec;68 (6) :920-7.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CYP3

• CAS Number:

  [173026-17-0]