Products for Research Use Only
RegisterLogin

ALT-2074

CAT: 0804-HY-W879508Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-W879508Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
ALT-2074 (BXT-51071) is an orally active catalytic analogue of glutathione peroxidase. ALT-2074 is an inhibitor of human CYP3A, with its IC50 value ranging from 2.0 to 2.6 μM. ALT-2074 shows only a weak inhibitory effect on CYP3A in vivo, suggesting that it may not significantly affect the metabolism of CYP3A substrate drugs. ALT-2074 can be used to study inflammatory diseases characterized by reactive oxygen species, such as acute coronary syndrome[1].
CAS Number
173026-17-0
Product Name Alternative
BXT-51072
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Cytochrome P450; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
CC1(C)CN[Se]C2=C1C=CC=C2
Molecular Formula
C10H13NSe
Molecular Weight
226.18
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Greenblatt DJ, et al. Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso- (2H) -selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase. Br J Clin Pharmacol. 2009 Dec;68 (6) :920-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP3

Chemical Information

Bxt 51072

An organoselenium drug previously studied by Oxis International in Phase-II clinical trials for ulcerative colitis patients. Some indications of efficacy were demonstrated. BXT-51072 has enthusiastic endorsement for treatment in cardiovascular indications, primarily because of its ability to mimic the function of glutathione peroxidase.

CAS Number173026-17-0
PubChem CID130165
IUPAC Name4,4-dimethyl-2,3-dihydro-1,2-benzoselenazine
Molecular FormulaC10H13NSe
Molecular Weight226.19
Topological Polar Surface Area12
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Heavy Atom Count12
Formal Charge0
Complexity167
SMILES
CC1(CN[Se]C2=CC=CC=C21)C
InChI
InChI=1S/C10H13NSe/c1-10(2)7-11-12-9-6-4-3-5-8(9)10/h3-6,11H,7H2,1-2H3
InChIKey
FXRYWOJYVGJZLE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Bxt 51072
CAS: 173026-17-0
CID: 130165
Formula: C10H13NSe
MW: 226.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight226.19
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count1
Rotatable Bond Count0
Exact Mass227.02132
Monoisotopic Mass227.02132
Topological Polar Surface Area12 Ų
Heavy Atom Count12
Formal Charge0
Complexity167
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-170794-01ALT-007
HY-P990320-01ALT-836 (TNX-832)
HY-P990319-01ALT-100 (Human IgG4)
HY-P991075-01ALT-100 (Human IgG1)
HY-W392258-01Poly (methyl vinyl ether-alt-maleic anhydride) (MW 216000)
HY-W392258APoly (methyl vinyl ether-alt-maleic anhydride) (MW 1080000)
HY-W129474RPoly (4-hydroxy-2,2,6,6-tetramethyl-1-piperidineethanol-alt-1,4-butanedioic acid) (Standard)
HY-119337CE-2072
HY-108592-01UCL 2077
HY-108079KOS-2079

Alternative Products

CatalogName
T205496-01ALT-007
CHALT 215HGPT/ALT
OACD01581-1MLALT Antibody
C0158ALT (GPT)
MA-0116ALT/SGPT
HBEL020GPT (ALT)
GTR19349296-01Alt a 1
TL313176CSB (ERCC6) Human shRNA Plasmid Kit (Locus ID 2074)
SR320072CSB (ERCC6) Human siRNA Oligo Duplex (Locus ID 2074)
TL313176VCSB (ERCC6) Human shRNA Lentiviral Particle (Locus ID 2074)

Popular Products