TFC 007

CAT: 0804-HY-110167Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-110167Size:1 mg
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Description
TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM) . TFC-007 can be used for composing H-PGDS degradation inducer PROTAC (H-PGDS) -1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) [1].
CAS Number
[927878-49-7]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; PGE synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tfc-007.html
Purity
98.01
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O=C(N1CCOCC1)C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2
Molecular Formula
C27H29N5O4
Molecular Weight
487.55
References & Citations
[1]Hidetomo Yokoo, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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