TFC 007

• Description :

  TFC-007, a selective hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, show high inhibitory activity against H-PGDS enzyme (IC50 value of 83 nM) . TFC-007 can be used for composing H-PGDS degradation inducer PROTAC (H-PGDS) -1 (TFC-007 binds to H-PGDS, and Pomalidomide binds to cereblon) [1].

• UNSPSC :

  12352005

• Target :

  Ligands for Target Protein for PROTAC; PGE synthase

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tfc-007.html

• Purity :

  98.01

• Solubility :

  DMSO : 1 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(N1CCOCC1)C2CCN(C3=CC=C(NC(C4=CN=C(OC5=CC=CC=C5)N=C4)=O)C=C3)CC2

• Molecular Formula :

  C27H29N5O4

• Molecular Weight :

  487.55

• References & Citations :

  [1]Hidetomo Yokoo, et al. Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer. ACS Med Chem Lett. 2021 Jan 14;12 (2) :236-241.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [927878-49-7]