CCI-007

• Description :

  CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cci-007.html

• Purity :

  98.45

• Solubility :

  DMSO : 83.33 mg/mL (ultrasonic)

• Smiles :

  O=C(OCC)COC1=CC=C(/C=C(SC(N)=N2)\C2=O)C=C1OC

• Molecular Formula :

  C15H16N2O5S

• Molecular Weight :

  336.36

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19;7 (29) :46067-46087.|[2]Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May;38 (20) :3824-3842.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [939228-52-1]