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CCI-007

CAT: 0804-HY-122698-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122698-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CCI-007 is a small molecule with cytotoxic activity against infant leukemia with MLL rearrangements, with IC50 values of 2.5-6.2 μM in sensitive cells[1].
CAS Number
939228-52-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cci-007.html
Purity
98.45
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
O=C(OCC)COC1=CC=C(/C=C(SC(N)=N2)\C2=O)C=C1OC
Molecular Formula
C15H16N2O5S
Molecular Weight
336.36
Precautions
H302, H315, H319, H335
References & Citations
[1]Klaartje Somers, et al. CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements. Oncotarget. 2016 Jul 19;7 (29) :46067-46087.|[2]Klaartje Somers, et al. A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction. Oncogene. 2019 May;38 (20) :3824-3842.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported