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TLR7 agonist 12

CAT: 0804-HY-154271Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-154271Size:1 Each
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Description
TLR7 agonist 12 (example 20) is a TLR7 agonist, also is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1][2].
CAS Number
2389988-47-8
UNSPSC
12352005
Target
Nucleoside Antimetabolite/Analog
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tlr7-agonist-12.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@@H](O)[C@H](N2C(N=C(N)NC3=O)=C3N(CCCC(O)=O)C2=O)O[C@@H]1CO
Molecular Formula
C14H19N5O8
Molecular Weight
385.33
References & Citations
[1]Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18 (23) :3373-88.|[2]Webber, et al. TLR7 agonists for treatment of cancer and infectious disease. World Intellectual Property Organization, WO2019226977 A1. 2019-11-28.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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