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PROTAC BTK Degrader-9

CAT: 0931-T209408-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209408-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
RANKL/RANK, BTK, PROTACs
Related Pathways
PROTAC, Tyrosine Kinase/Adaptors, NF-κB, Angiogenesis
Bioactivity
PROTACBTK Degrader-9 (compound 23) is a potent PROTACs degrader that specifically targets BTK. It effectively downregulates the RANKL-activated BTK-PLCγ2-Ca2+-NFATc1 signaling pathway. Consequently, PROTACBTK Degrader-9 inhibits osteoclastogenesis and reduces alveolar bone resorption in a mouse model of periodontitis.
Molecular Formula
C46H52FN13O5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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