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PROTAC EZH2 Degrader-9

CAT: 0013-GTR19275188-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19275188-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTACEZH2 Degrader-9 is an orally active EZH2 PROTAC degrader, operating through the ubiquitin-proteasome pathway. It effectively reduces the PRC2 core subunit and potently inhibits H3K27me3 without affecting common CRBN neo-substrates, showing selectivity towards GSPT1 and IKZF1/3. The compound exhibits strong antiproliferative effects on various cancer cell lines by inducing cell cycle arrest and apoptosis (apoptosis) . Additionally, PROTACEZH2 Degrader-9 reverses PRC2-mediated gene silencing and suppresses the activation of EZH2 non-catalytic target genes. This compound is applicable in research on leukemia, lymphoma, and non-small cell lung cancer.
CAS Number
2978620-84-5
Smiles
O=C (NCC=1C (=O) NC (=CC1C) C) C2=CC (=CC (=C2C) N (CC) C3CCOCC3) C4=CC=C (C=C4) CN5CCC6 (CN (C7=CC=C8C (=O) N (C (=O) C8=C7) C9C (=O) NC (=O) CC9) CC6) CC5
Molecular Formula
C51H59N7O7
Molecular Weight
882.08
Storage Conditions
-20°C
Notes
For research use only.

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