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LSD1-IN-38

CAT: 0804-HY-170403Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170403Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor for lysine specific demethylase 1 (LSD1) with an IC50 of 1.2 nM. LSD1-IN-38 inhibits the proliferation of cancer cells MV4-11, Kasumi-1 and NCI-H526, with IC50 of 5, 4 and 11 nM, respectively. LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM, and induces differentiation in MV4 11 cell. LSD1-IN-38 exhibits antitumor efficacy in mouse models[1].
UNSPSC
12352005
Target
Histone Demethylase
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC1=C(C#N)C=CC(C2=C(N=CC3=C2C=C(CN4C[C@@H](N)CC4)N3CC(F)(F)F)C5=CC(C)=C(C)C=C5C)=C1
Molecular Formula
C30H29F4N5
Molecular Weight
535.58
References & Citations
[1]Jiang H, et al., Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia. J Med Chem. 2024 Dec 26;67 (24) :22080-22103.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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