LSD1-IN-38

• Target:

  Histone Demethylase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 1.2 nM. It effectively inhibits the proliferation of cancer cells MV4-11, Kasumi-1, and NCI-H526 with IC50 values of 5, 4, and 11 nM, respectively. Furthermore, LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 ?M and induces differentiation in MV4-11 cells. In mouse models, this compound demonstrates antitumor activity.

• Smiles:

  CC1=CC(=C(C=C1C)C2=NC=C3C(=C2C4=CC(=C(C=C4)C#N)F)C=C(N3CC(F)(F)F)CN5CC[C@@H](C5)N)C

• Molecular Formula:

  C30H29F4N5

• Molecular Weight:

  535.578

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C