LSD1-IN-38

CAT: 0931-T204124-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T204124-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Target

Histone Demethylase

Related Pathways

Chromatin/Epigenetic

Bioactivity

LSD1-IN-38 (Compound 23e) is a reversible, orally active inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 1.2 nM. It effectively inhibits the proliferation of cancer cells MV4-11, Kasumi-1, and NCI-H526 with IC50 values of 5, 4, and 11 nM, respectively. Furthermore, LSD1-IN-38 activates CD86 expression with an EC50 of 0.034 μM and induces differentiation in MV4-11 cells. In mouse models, this compound demonstrates antitumor activity.

Smiles

CC1=CC(=C(C=C1C)C2=NC=C3C(=C2C4=CC(=C(C=C4)C#N)F)C=C(N3CC(F)(F)F)CN5CC[C@@H](C5)N)C

Molecular Formula

C30H29F4N5

Molecular Weight

535.578

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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HY-170403	LSD1-IN-38
bs-60179C-01	GSK-LSD1 --- LSD1 Inhibitor
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BA4801-5.1	LSD1-IN-24
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LSD1-IN-38

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