STAT3-IN-37

• Description:

  STAT3-IN-37 (Compound 101) is the inhibitor for STAT3 with an IC50 of 15 nM (measuring by DNA-HTRF assay) or 2 nM (measuring by human whole blood SOCS3 qPCR assay) [1].

• UNSPSC:

  12352005

• Target:

  STAT

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  O=C1NN=CC(CCCN2CC3(CC(C3)CC(C=CC(Cl)=C45)=C5C=NN(C)C4=O)C2)=C1Cl

• Molecular Formula:

  C23H25Cl2N5O2

• Molecular Weight:

  474.38

• References & Citations:

  [1]Wu Q, et al., 2-azaspiro[3.3]heptane derivatives as stat3 inhibitors for the treatment of cancer. WO2024182693A1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  STAT3

• CAS Number:

  [3055844-98-6]