AP-1

• Description :

  AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK) . AP-1 is composed of PROTAC target protein ligand CS-1243648 (HY-169482) (red part), E3 ligase ligand Pomalidomide (HY-10984) (blue part) and PROTAC Linker 2- (Tert-Butoxy) -2-oxoacetic acid (HY-W687662) (black part) [1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK) ; PROTACs

• Related Pathways :

  PROTAC; Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Purity :

  97.8

• Smiles :

  O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(CC4)C5=CC=C(C(OC)=C5)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl)=O)=CC=C3)=O)=O

• Molecular Formula :

  C39H40ClN9O8S

• Molecular Weight :

  830.31

• References & Citations :

  [1]Lidong Gong, et al. Discovery of a miniaturized PROTAC with potent activity and high selectivity. Bioorg Chem. 2023 Jul:136:106556.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3027918-96-0]