AP-1

CAT: 0804-HY-169481-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-169481-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AP-1 is a PROTAC targeting anaplastic lymphoma kinase (ALK). AP-1 is composed of PROTAC target protein ligand CS-1243648 (red part), E3 ligase ligand Pomalidomide (HY-10984) (blue part) and PROTAC Linker 2- (Tert-Butoxy) -2-oxoacetic acid (HY-W687662) (black part).

CAS Number

3027918-96-0

UNSPSC

12352005

Target

Anaplastic lymphoma kinase (ALK) ; PROTACs

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Purity

97.8

Smiles

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCC(N4CCN(CC4)C5=CC=C(C(OC)=C5)NC6=NC=C(C(NC7=C(S(=O)(C(C)C)=O)C=CC=C7)=N6)Cl)=O)=CC=C3)=O)=O

Molecular Formula

C39H40ClN9O8S

Molecular Weight

830.31

References & Citations

[1]Lidong Gong, et al. Discovery of a miniaturized PROTAC with potent activity and high selectivity. Bioorg Chem. 2023 Jul:136:106556.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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HY-153538-01	AP-C2
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T83856-01	AP-1
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533091-01	AP-1 discontinued
MBS6124640-01	Endothelin 1 (AP)
B0867-01	AP-1 Antibody
sc-166441	AP-2β (A-1)
MBS6257847-01	RanGAP 1 (AP)
MBS6241678-01	Fibrillin 1 (AP)

AP-1

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