LTD4 antagonist 2

• Description :

  LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R) . LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1][2].

• CAS Number :

  [107813-86-5]

• UNSPSC :

  12352005

• Target :

  Leukotriene Receptor

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Smiles :

  O=C(C1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)O

• Molecular Formula :

  C17H13NO3

• Molecular Weight :

  279.29

• References & Citations :

  [1]Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64 (22) :16512-16529.|[2]Musser JH, et al. N-[ (arylmethoxy) phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem. 1990 Jan;33 (1) :240-5.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported