LTD4 antagonist 2

CAT: 0804-HY-168784-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-168784-01Size:1 mg
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Description
LTD4 antagonist 2 (compound 6) is a leukotriene D4 (LTD4) antagonist with an IC50 of 2.8 μM against cysteinyl leukotriene 1 receptor (CysLT1R) . LTD4 antagonist 2 is also a G protein-coupled bile acid receptor 1 (GPBAR1) agonist and can be utilized in research related to colitis, metabolic syndromes, and other GPBAR1/CysLT1R-related diseases[1][2].
CAS Number
[107813-86-5]
UNSPSC
12352005
Target
Leukotriene Receptor
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(C1=CC(OCC2=NC3=C(C=C2)C=CC=C3)=CC=C1)O
Molecular Formula
C17H13NO3
Molecular Weight
279.29
References & Citations
[1]Fiorillo B, et al. Structural Basis for Developing Multitarget Compounds Acting on Cysteinyl Leukotriene Receptor 1 and G-Protein-Coupled Bile Acid Receptor 1. J Med Chem. 2021 Nov 25;64 (22) :16512-16529.|[2]Musser JH, et al. N-[ (arylmethoxy) phenyl] carboxylic acids, hydroxamic acids, tetrazoles, and sulfonyl carboxamides. Potent orally active leukotriene D4 antagonists of novel structure. J Med Chem. 1990 Jan;33 (1) :240-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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