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MCHR1 antagonist 2

CAT: 0804-HY-100321-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100321-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MCHR1 antagonist 2 is an antagonist of melanin concentrating hormone receptor 1, with an IC50 of 65 nM; MCHR1 antagonist 2 also inhibits hERG, with an IC50 of 4.0 nM in IMR-32 cells[1].
CAS Number
863115-70-2
UNSPSC
12352005
Target
MCHR1 (GPR24) ; Potassium Channel
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MCHr1_antagonist_2.html
Purity
98.27
Solubility
DMSO : 10 mg/mL (ultrasonic; adjust pH to 6 with HCl)
Smiles
O=C(C1=CC(C2=CC(F)=CC=C2O1)=O)NC3CCN(CC4=CC=C(OCO5)C5=C4)CC3
Molecular Formula
C23H21FN2O5
Molecular Weight
424.42
References & Citations
[1]Lynch JK, et al. Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety. J Med Chem. 2006 Nov 2;49 (22) :6569-84.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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