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β-AR antagonist 2

CAT: 0804-HY-163363Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163363Size:1 Each
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Description
β-AR antagonist 2 (compound 43) is an antagonist of β-AR (IC50: 0.17 μM) . β-AR-IN-1 inhibits the growth of mouse A549 xenograft tumors and shows cardioprotective efficacy against DOX-induced HF in C57 mice[1].
CAS Number
2779507-62-7
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/β-ar-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=CC=C1/C=C/CNCC(O)COC2=CC=C(NC3=CC=CC=C3)C=C2
Molecular Formula
C25H28N2O3
Molecular Weight
404.50
References & Citations
[1]Chen X, et al. Trilogy of drug repurposing for developing cancer and chemotherapy-induced heart failure co-therapy agent. Acta Pharm Sin B. 2024 Feb;14 (2) :729-750.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported