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RXR antagonist 2

CAT: 0804-HY-144383Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-144383Size:1 Each
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Description
RXR antagonist 2 (compound 6b) is a potent antagonist of RXR with a Ki and Kd of 0.391 and 0.281 μM. RXR antagonist 2 has the potential for the research of RXR related diseases[1].
CAS Number
3010910-41-2
UNSPSC
12352005
Target
RAR/RXR
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/rxr-antagonist-2.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=NC2=C(C=CC(C(O)=O)=C2)N1C3=CC(C(C)(CCC4(C)C)C)=C4C=C3OCCCCCC
Molecular Formula
C29H35F3N2O3
Molecular Weight
516.60
References & Citations
[1]Watanabe M, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med Chem Lett. 2022 Jan 21;13 (2) :211-217.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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