LTD4 antagonist 1

• Description:

  LTD4 antagonist 1 is a potent, orally active antagonist of leukotriene D4 (LTD4) with a Ki of 0.57 nM.

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/1H-Indole-5-carboxamide,_3-[[2-methoxy-4-[[[_2-methylphenyl_sulfonyl]amino]carbonyl]phenyl]methyl]-1-methyl-N-_4,4,4-trifluoro-2-methylbutyl_-.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC2=C(N(C)C=C2CC3=CC=C(C(NS(=O)(C4=CC=CC=C4C)=O)=O)C=C3OC)C=C1)NCC(C)CC(F)(F)F

• Molecular Formula:

  C31H32F3N3O5S

• Molecular Weight:

  615.66

• References & Citations:

  [1]Robert T. Jacobs, et al. Synthesis, Structure-Activity Relationships, and Pharmacological Evaluation of a Series of Fluorinated 3-Benzyl-5-Indolecarboxamides: Identification of 4-[[5-[ ((2R) -2-Methyl-4,4,4-trifluorobutyl) carbamoyl]-1-methylindol-3-yl]methyl]-3methoxy-N-[ (2-methylphenyl) sulfonyl]benzamide, a Potent, Orally Active Antagonist of Leukotrienes D4 and E4. Journal of Medicinal Chemistry (1994), 37 (9), 1282-97.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  LTD4/CysLT1

• CAS Number:

  [136564-67-5]