LTD4 antagonist 3

• Description:

  LTD4 antagonist 3 (FK011 hydrochloride) is a LTD4 antagonist. LTD4 antagonist 3 has agonistic activity for PPAR-γ, with a fold-increase of 1.50 at 1 μM and 2.35 at 10 μM. LTD4 antagonist 3 can be used of development of non-steroidal anti-inflammatory drugs (NSAIDs) [1].

• Product Name Alternative:

  FK011 (hydrochloride)

• UNSPSC:

  12352005

• Target:

  Leukotriene Receptor; PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; GPCR/G Protein; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Inflammation/Immunology

• Smiles:

  O=C(CC1=C(COC2=CC3=C(OC(C4=NC(C(C)(C)C)=CS4)=C3)C=C2)C=CC=C1)O.Cl

• Molecular Formula:

  C24H24ClNO4S

• Molecular Weight:

  457.97

• References & Citations:

  [1]Kojo H, et al. Evaluation of human peroxisome proliferator-activated receptor (PPAR) subtype selectivity of a variety of anti-inflammatory drugs based on a novel assay for PPAR delta (beta) . J Pharmacol Sci. 2003 Nov;93 (3) :347-55.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• Isoform:

  LTD4/CysLT1; PPARγ

• CAS Number:

  [149437-51-4]