MI-888 (TFA)

• Description :

  MI-888 (TFA) is an orally active MDM2-p53 interaction inhibitor with a Ki of 0.44 nM. MI-888 (TFA) can achieve rapid, complete, and sustained tumor regression in a xenograft mouse model of cancer[1].

• UNSPSC :

  12352005

• Target :

  MDM-2/p53

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Smiles :

  O=C([C@H](N[C@H]1CC(C)(C)C)[C@H](C2=CC=CC(Cl)=C2F)[C@@]31C(NC4=C3C=CC(Cl)=C4)=O)N[C@H]5C[C@](C)(O)C5.O=C(O)C(F)(F)F

• Molecular Formula :

  C30H33Cl2F4N3O5

• Molecular Weight :

  662.50

• References & Citations :

  [1]Zhao Y, et al. A potent small-molecule inhibitor of the MDM2-p53 interaction (MI-888) achieved complete and durable tumor regression in mice. J Med Chem. 2013 Jul 11;56 (13) :5553-61.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1303609-30-4]