MI-1061 TFA

• Target:

  Others|||Apoptosis|||E1/E2/E3 Enzyme|||MDM-2/p53

• Related Pathways:

  Ubiquitination|||Others|||Apoptosis

• Bioactivity:

  MI-1061 TFA, a potent and orally bioavailable MDM2 inhibitor (MDM2-p53 interaction), demonstrates significant chemical stability with an IC 50 of 4.4 nM and a K i of 0.16 nM. It effectively activates p53 and induces apoptosis within SJSA-1 xenograft tumor tissues in mice, showcasing notable anti-tumor activity [1].

• Smiles:

  C(C(O)=O)(F)(F)F.O=C1[C@@]2(C3(N[C@@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6

• Molecular Formula:

  C32H27Cl2F4N3O6

• Molecular Weight:

  696.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1410737-35-7