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MI-1061 TFA

CAT: 0931-T73895-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0931-T73895-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1410737-35-7
Target
Others|||Apoptosis|||E1/E2/E3 Enzyme|||MDM-2/p53
Related Pathways
Ubiquitination|||Others|||Apoptosis
Bioactivity
MI-1061 TFA, a potent and orally bioavailable MDM2 inhibitor (MDM2-p53 interaction), demonstrates significant chemical stability with an IC 50 of 4.4 nM and a K i of 0.16 nM. It effectively activates p53 and induces apoptosis within SJSA-1 xenograft tumor tissues in mice, showcasing notable anti-tumor activity [1].
Smiles
C(C(O)=O)(F)(F)F.O=C1[C@@]2(C3(N[C@@H](C(NC4=CC=C(C(O)=O)C=C4)=O)[C@@H]2C5=C(F)C(Cl)=CC=C5)CCCCC3)C=6C(N1)=CC(Cl)=CC6
Molecular Formula
C32H27Cl2F4N3O6
Molecular Weight
696.47
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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