BIBW 2992

• Background:

  BIBW 2992 is a potent and irreversible ErbB inhibitor. It has also been shown to inhibit EGFR/Neu.

• Description:

  EGFR, HER2 kinase inhibitor

• Product Name Alternative:

  Afatinib, N-​[4-​[ (3-​chloro-​4-​fluorophenyl) amino]-​7-​[[ (3S) -​tetrahydro-​3-​furanyl]oxy]-​6-​quinazolinyl]-​4-​ (dimethylamino) -​2-​butenamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  >99%

• Weight:

  0.005

• Format:

  Crystalline solid

• Solubility:

  Soluble in DMSO at 200 mg/ml; in ethanol at 25 mg/ml

• Molecular Formula:

  C24H25ClFN5O3

• Molecular Weight:

  485.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ioannou, N., et al. (2011) Br. J. Cancer. 105(10): 1554–1562.

• CAS Number:

  850140-72-6