GDC-2992

• Target:

  Androgen Receptor|||PROTACs

• Related Pathways:

  Endocrinology/Hormones|||PROTAC

• Purity:

  0.9982

• Bioactivity:

  GDC-2992 is a selective and orally active androgen receptor (AR) degradator that degrades AR (DC50 = 2.7 nM) and inhibits proliferation (IC50 = 9.7 nM) in VCaP cells, making it suitable for studying castration-resistant prostate cancer (CRPC) .

• Smiles:

  O ([C@H]1C (C) (C) [C@H] (NC (=O) C2=CC=C (C=C2) N3CCC (CN4CCN (CC4) C=5C=C6C (=CC5) C (=O) N (N=C6) [C@@H]7C (=O) NC (=O) CC7) CC3) C1 (C) C) C8=CC (Cl) =C (C#N) C=C8

• Molecular Formula:

  C45H51ClN8O5

• Molecular Weight:

  819.39

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2753651-10-2