PRMT5-IN-46

• Description:

  PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC50s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H320

• Target:

  Histone Methyltransferase

• Related Pathways:

  Epigenetics

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Smiles:

  ClC1=CC=C(COCC(CN2CC3=C(CC2)C=CC=C3)O)C=C1

• Molecular Formula:

  C19H22ClNO2

• Molecular Weight:

  331.84

• Precautions:

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations:

  [1]DUNCAN, et al. PRMT5 inhibitors and uses thereof. WO2014100695. World Intellectual Property Organization. 2014-06-26.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [380192-76-7]