PRMT5-IN-46

• Description :

  PRMT5-IN-46 (compound 278) inhibits PRMT5 with IC50s of 1-10 μM. PRMT5 is a methyltransferase which is associated with specific genetic alterations. PRMT5-IN-46 can be used for research of proliferative diseases, metabolic disorders, and blood diseases[1].

• CAS Number :

  [380192-76-7]

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H320

• Target :

  Histone Methyltransferase

• Related Pathways :

  Epigenetics

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Smiles :

  ClC1=CC=C(COCC(CN2CC3=C(CC2)C=CC=C3)O)C=C1

• Molecular Formula :

  C19H22ClNO2

• Molecular Weight :

  331.84

• Precautions :

  P264-P280-P302+P352-P305+P351+P338-P362

• References & Citations :

  [1]DUNCAN, et al. PRMT5 inhibitors and uses thereof. WO2014100695. World Intellectual Property Organization. 2014-06-26.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 1