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MK-1220

CAT: 0804-HY-14404Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14404Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MK-1220 is a covalently reversible inhibitor of the hepatitis C virus (HCV) NS3/4A protease (NS3/4A protease) with a Ki of 0.02 nM. MK-1220 in cell models simulating viral replication exhibits EC50s of 4 (with 10% fetal bovine serum) and 11 nM (50% normal human serum) . MK-1220 can be used for the study of chronic hepatitis C virus infection[1].
CAS Number
[924270-31-5]
UNSPSC
12352005
Target
HBV; HCV Protease
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
CC(C)(COC(N[C@@H](C1CCCCC1)C(N2[C@H](C(N[C@@](C3)(C(NS(=O)(C4CC4)=O)=O)[C@@H]3C=C)=O)C[C@@H](O5)C2)=O)=O)CCCC6=C(OC)C=C7C(C5=NC=C7)=C6
Molecular Formula
C40H53N5O9S
Molecular Weight
779.94
References & Citations
[1]Rudd MT, et al. Discovery of MK-1220: A Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure. ACS Med Chem Lett. 2011 Jan 12;2 (3) :207-12.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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