MK-2894

CAT: 0804-HY-10413-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-10413-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
MK-2894 is a potent, selective, orally active and high affinity (Ki=0.56 nM) full antagonist against E prostanoid receptor 4 (EP4 receptor) (IC50=2.5 nM) . MK-2894 possesses potent anti-inflammatory activity in animal models of pain/inflammation and can be used for the research of arthritis[1][2].
CAS Number
[1006036-87-8]
UNSPSC
12352005
Target
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MK-2894.html
Concentration
10mM
Purity
99.31
Solubility
DMSO : ≥ 50 mg/mL
Smiles
O=C(O)C1=CC=C(C2(NC(C3=C(C)SC(C)=C3CC4=CC=C(C(F)(F)F)C=C4)=O)CC2)C=C1
Molecular Formula
C25H22F3NO3S
Molecular Weight
473.51
References & Citations
[1]Blouin M, et al. The discovery of 4-{1-[ ({2,5-dimethyl-4-[4- (trifluoromethyl) benzyl]-3-thienyl}carbonyl) amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem. 2010 Mar 11;53 (5) :2227-38.|[2]Tijana Markovič, et al. Structural features of subtype-selective EP receptor modulators. Drug Discov Today. 2017 Jan;22 (1) :57-71.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EP

Related Products

CatalogName
HY-112319MK-8457
HY-120233MK-8876
HY-11072MK-0359
HY-P991581MK-2060
HY-P991406MK-1248
HY-P991179-01MK-4166
HY-18612MK-7725
HY-14404MK-1220
HY-13299-01MK-8033
HY-117967MK-6169

Alternative Products

CatalogName
MBS5753493MK-2894
A11497-1MK-2894 1mg
A11497-50MK-2894 50mg
A11497-5MK-2894 5mg
A11497-10MK-2894 10mg
A11497-500MK-2894 500mg
A11497-25MK-2894 25mg
A11497-100MK-2894 100mg
MBS5753492MK-2894 sodium salt
A11498-10MK-2894 sodium salt 10mg

Popular Products