ZZM-1220

• Target:

  Histone Methyltransferase|||Apoptosis

• Related Pathways:

  Chromatin/Epigenetic|||Apoptosis

• Bioactivity:

  ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP. It effectively inhibits H3K9me2 in cells, induces apoptosis in triple-negative breast cancer (TNBC) cells, and arrests the cell cycle at the G2/M phase [1].

• Molecular Formula:

  C25H29N5O3

• Molecular Weight:

  447.53

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C