ZZM-1220

• Target :

  Histone Methyltransferase|||Apoptosis

• Related Pathways :

  Chromatin/Epigenetic|||Apoptosis

• Bioactivity :

  ZZM-1220, a covalent inhibitor of histone lysine methyltransferase G9a/GLP, exhibits IC50 values of 458 nM for G9a and 924 nM for GLP. It effectively inhibits H3K9me2 in cells, induces apoptosis in triple-negative breast cancer (TNBC) cells, and arrests the cell cycle at the G2/M phase [1].

• Molecular Formula :

  C25H29N5O3

• Molecular Weight :

  447.53

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C