MK-886

MK-886

• CAS Number: 118414-82-7
• UNSPSC Description: MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].
• Target Antigen: Apoptosis; FLAP; Leukotriene Receptor; PPAR
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;GPCR/G Protein;Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/MK-886.html
• Solubility: DMSO : 75 mg/mL (ultrasonic)
• Smiles: CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1
• Molecular Weight: 472.08
• References & Citations: [1]Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR)alpha by MK886. Biochem J. 2001 Jun 15.|[2]Gillard J et al. L-663,536 (MK-886) (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67(5):456-64.
• Shipping Conditions: Room Temperature
• Clinical Information: Phase 2