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MK-886

CAT: 0804-HY-14166-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-14166-01Size:1 mg
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Description
MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP (IC50 of 30 nM) and leukotriene biosynthesis (IC50s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis[1][2][3].
CAS Number
118414-82-7
Product Name Alternative
L 663536
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; FLAP; Leukotriene Receptor; PPAR
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/MK-886.html
Concentration
10mM
Purity
99.87
Solubility
DMSO : 75 mg/mL (ultrasonic)
Smiles
CC(C)C1=CC=C(N(CC2=CC=C(Cl)C=C2)C(CC(C)(C(O)=O)C)=C3SC(C)(C)C)C3=C1
Molecular Formula
C27H34ClNO2S
Molecular Weight
472.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Kehrer JP et al. Inhibition of peroxisome-proliferator-activated receptor (PPAR) alpha by MK886. Biochem J. 2001 Jun 15.|[2]Gillard J et al. L-663,536 (MK-886) (3-[1- (4-chlorobenzyl) -3-t-butyl-thio-5-isopropylindol-2-yl]-2,2 - dimethylpropanoic acid), a novel, orally active leukotriene biosynthesis inhibitor. Can J Physiol Pharmacol. 1989 May;67 (5) :456-64.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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BML-EI266-0005MK-886
MBS131098-01MK 886

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