BTL-MK

• UNSPSC Description:

  BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978)-induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability[1].

• Target Antigen:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/btl-mk.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1=CC=C(C=C1C/C=C(C)\C)C[C@]2(OC(C(O)=C2C3=CC=C(C=C3)O)=O)C(C)=O

• Molecular Weight:

  408.44

• References & Citations:

  [1]Xie CL, et al., Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. J Med Chem. 2024 May 9;67(9):7504-7515.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2758569-43-4