BTL-MK

CAT: 0804-HY-158316Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-158316Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978) -induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability[1].
CAS Number
[2758569-43-4]
UNSPSC
12352005
Target
Fc Receptor (FcR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/btl-mk.html
Solubility
10 mM in DMSO
Smiles
OC1=CC=C(C=C1C/C=C(C)\C)C[C@]2(OC(C(O)=C2C3=CC=C(C=C3)O)=O)C(C)=O
Molecular Formula
C24H24O6
Molecular Weight
408.44
References & Citations
[1]Xie CL, et al., Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. J Med Chem. 2024 May 9;67 (9) :7504-7515.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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