BTL-MK

• Description :

  BTL-MK (Compound 19) an orally active antiallergic agent, that inhibits degranulation of mast cells with an IC50 of 6.7 μM, through binding to the inhibitory receptor FcγRIIB. BTL-MK improves the metaboilic stability in human liver microsomes. BTL-MK ameliorates the allergic response in Ovalbumins (HY-W250978) -induced food allergy mice model. BTL-MK exhibits a good pharmacokinetic character with metabolic stability[1].

• CAS Number :

  [2758569-43-4]

• UNSPSC :

  12352005

• Target :

  Fc Receptor (FcR)

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/btl-mk.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC1=CC=C(C=C1C/C=C(C)\C)C[C@]2(OC(C(O)=C2C3=CC=C(C=C3)O)=O)C(C)=O

• Molecular Formula :

  C24H24O6

• Molecular Weight :

  408.44

• References & Citations :

  [1]Xie CL, et al., Lead Optimization of Butyrolactone I as an Orally Bioavailable Antiallergic Agent Targeting FcγRIIB. J Med Chem. 2024 May 9;67 (9) :7504-7515.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported