RegisterLogin

(R) -CMPD-39

CAT: 0804-HY-141659A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-141659A-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
(R) -CMPD-39 is the R enantiomer of CMPD-39 (HY-141659) . CMPD-39 is a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 (IC50 =~20 nM), with high selectivity over other DUB family members (1-100 μM) . CMPD-39 inhibits the deubiquitinating activity of USP30, enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP; thus, CMPD-39 promotes phosphoubuitin accumulation, thereby accelerating mitochondrial autophagy (mitophagy) and peroxisomal autophagy (pexophagy) . CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson's disease patients[1][2].
UNSPSC
12352005
Target
Deubiquitinase; Mitophagy
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
99.78
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O
Molecular Formula
C26H28FN3O4S
Molecular Weight
497.58
References & Citations
[1]Kluge AF, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28 (15) :2655-2659. |[2]Rusilowicz-Jones EV, et al. Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. Life Sci Alliance. 2021 Nov 29;5 (2) :e202101287.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-141659-01CMPD-39
HY-P5672Maximin 39
HY-170389BChE-IN-39
HY-157107ICMT-IN-39
HY-149473AChE-IN-39
HY-129314CM-39
HY-157665HSD17B13-IN-39
HY-160845HDAC6-IN-39
HY-149520HPK1-IN-39
HY-159956BTK-IN-39

Alternative Products

CatalogName
TYD-02872-01(R) -CMPD-39
MBS5813168Cmpd-A
T25267-01Cmpd 339509
444930-01CMPD-1
PHY5370SCmpD Antibody
A16040-5CMPD-1 5mg
A16040-25CMPD-1 25mg
A16040-500CMPD-1 500mg
A16040-10CMPD-1 10mg
A16040-100CMPD-1 100mg

Popular Products