(R) -CMPD-39

• Target:

  DUB|||Mitophagy

• Related Pathways:

  Ubiquitination|||Cell Cycle/Checkpoint|||Autophagy|||DNA Damage/DNA Repair

• Bioactivity:

  (R) -CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 ?M. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C