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(R) -CMPD-39

CAT: 0931-TYD-02872-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-TYD-02872-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
DUB, Mitophagy
Related Pathways
Ubiquitination, Cell Cycle/Checkpoint, Autophagy, DNA Damage/DNA Repair
Bioactivity
(R) -CMPD-39 is the R-enantiomer of CMPD-39. CMPD-39 acts as a selective non-covalent inhibitor of the ubiquitin-specific protease USP30 with an IC50 of approximately 20 nM and demonstrates high selectivity for other DUB family members at concentrations ranging from 1-100 μM. By inhibiting USP30's deubiquitination activity, CMPD-39 enhances the ubiquitination of mitochondrial proteins TOMM20 and SYNJ2BP and promotes the accumulation of phosphorylated ubiquitin. This process accelerates both mitophagy and pexophagy. Additionally, CMPD-39 significantly restores impaired mitochondrial function in dopaminergic neurons derived from Parkinson’s disease patients.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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