CMPD-39

• UNSPSC Description:

  CMPD-39 is a selective USP30 inhibitor with an IC50 of 0.02 μM. CMPD-39 increases protein ubiquitination and accelerates mitophagy[1].

• Target Antigen:

  Deubiquitinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/usp30-inhibitor-18.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC(C)(C)NS(=O)(C1=CC=C(C=C1)NC([C@@H](NC(C2=CC=C(C=C2)F)=O)CC3=CC=CC=C3)=O)=O

• Molecular Weight:

  497.58

• References & Citations:

  [1]Arthur F Kluge, et al. Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy. Bioorg Med Chem Lett. 2018 Aug 15;28(15):2655-2659.|[2]Rusilowicz-Jones EV, Barone FG, Lopes FM, et al. Benchmarking a highly selective USP30 inhibitor for enhancement of mitophagy and pexophagy. Life Sci Alliance. 2021;5(2):e202101287.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2242582-40-5