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BChE-IN-39

CAT: 0804-HY-170389Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170389Size:1 Each
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Description
BChE-IN-39 (Compound 7c) is a selective inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.08 μM (IC50=3.98 μM for AChE) . BChE-IN-39 downregulates the GSK-3β expression, inhibits the hyperphosphorylation of tau protein[1].
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
FC1=CC(C[N+]2=CC=CC(CNC(C3=CC=C(CN(C(C4=C5C=CC=C4)=O)C5=O)C=C3)=O)=C2)=CC=C1.[Cl-]
Molecular Formula
C29H23ClFN3O3
Molecular Weight
515.96
References & Citations
[1]Noori M, et al., Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer's Disease. ACS Omega. 2024 Nov 25;9 (49) :48032-48043.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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