BChE-IN-39

• Description:

  BChE-IN-39 (Compound 7c) is a selective inhibitor for butyrylcholinesterase (BChE) with an IC50 of 0.08 μM (IC50=3.98 μM for AChE) . BChE-IN-39 downregulates the GSK-3β expression, inhibits the hyperphosphorylation of tau protein[1].

• UNSPSC:

  12352005

• Target:

  Cholinesterase (ChE)

• Related Pathways:

  Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Smiles:

  FC1=CC(C[N+]2=CC=CC(CNC(C3=CC=C(CN(C(C4=C5C=CC=C4)=O)C5=O)C=C3)=O)=C2)=CC=C1.[Cl-]

• Molecular Formula:

  C29H23ClFN3O3

• Molecular Weight:

  515.96

• References & Citations:

  [1]Noori M, et al., Isoindolinedione-Benzamide Pyridinium Derivatives for Targeting Alzheimer's Disease. ACS Omega. 2024 Nov 25;9 (49) :48032-48043.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  AChE; BChE