TEAD-IN-1

• Description :

  TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2].

• CAS Number :

  [2412761-57-8]

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  YAP

• Related Pathways :

  Stem Cell/Wnt

• Field of Research :

  Cancer

• Purity :

  99.43

• Smiles :

  CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O

• Molecular Formula :

  C15H20F2N2O3S

• Molecular Weight :

  346.39

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31 (12) :107809. |[2]Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TEAD