TEAD-IN-1

• Description:

  TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  YAP

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Cancer

• Purity:

  99.43

• Smiles:

  CS(=O)(NC1=CC(/C=C/C2CCC(F)(F)CC2)=C(OC)N=C1)=O

• Molecular Formula:

  C15H20F2N2O3S

• Molecular Weight:

  346.39

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31 (12) :107809. |[2]Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TEAD

• CAS Number:

  [2412761-57-8]