TEAD-IN-8

TEAD-IN-8

• CAS Number: 1008768-41-9
• UNSPSC Description: TEAD-IN-8 is a novel TEAD inhibitor, which potently and specifically inhibits TEAD-YAP transcriptional activities. TM2, alone or in combination with MEK inhibitors, exhibits potent antiproliferative effects in YAP-dependent cancer cells[1].
• Target Antigen: YAP
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/tead-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N1CCN(CC1)C(C2=CC(OCCC3CCCCC3)=CC=C2)=O)NC4=CC=CC=C4
• Molecular Weight: 435.56
• References & Citations: [1]Hu L, et al. Discovery of a new class of reversible TEA domain transcription factor inhibitors with a novel binding mode. Elife. 2022 Nov 18;11:e80210.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported