Pan-TEAD-IN-1

CAT: 0931-T203500-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T203500-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3027484-09-6

Target

YAP

Related Pathways

Stem Cells

Bioactivity

Pan-TEAD-IN-1 (Compound 3) is an orally active pan-inhibitor of TEAD, disrupting its interaction with coactivators YAP/TAZ by targeting the palmitoylation site of TEAD. This inhibition leads to the downregulation of oncogene transcription, such as Ctgf and Cyr61, within the Hippo signaling pathway. Demonstrating outstanding efficacy, pan-TEAD-IN-1 has an IC50 of 0.36 nM for luciferase and 1.52 nM for H226 cells, along with favorable pharmacokinetic properties (AUC0–∞= 228.7 μg/mL·min, T1/2= 183.9 min) . The compound significantly inhibits tumor growth in xenograft models of TEAD-dependent cancers, indicating its potential for research in these cancer types.

Smiles

O=C(C=C)N1CC=2C=C(C=CC2CC1)C3=CC=C(C=C3)C(F)(F)F

Molecular Formula

C19H16F3NO

Molecular Weight

331.33

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Alternative Products

Catalog	Name
HY-159912	Pan-TEAD-IN-1
C15575-01	PAN TEAD Antibody [A12P9]
C05395-100ul	Pan-TEAD Rabbit mAb
C19076-50uL	Pan-TEAD Antibody [L14N23]
NBP3-22659-100ul	Rabbit Monoclonal TEAD (pan) Antibody (SR1966)
CST 13295T	Pan-TEAD (D3F7L) Rabbit Monoclonal Antibody
GTR19249775-01	TEAD-IN-1
CST 10511S	Pan-TEAD (D3F7L) Rabbit Monoclonal Antibody (Biotinylated)
HY-P2244-01	YAP-TEAD-IN-1
GTR19249867-01	YAP/TEAD-IN-1

Pan-TEAD-IN-1

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