TEAD-IN-23

• Description:

  TEAD-IN-23 (Compound 22) is an efficient pan-TEAD inhibitor with an IC50 of 10 nM. TEAD-IN-23 exhibits potent anti-proliferative activity in both NCI-H226 and MSTO-211H. TEAD-IN-23 causes complete tumor regression in the MSTO-211H xenograft tumor model. TEAD-IN-23 can be used for the study of mesothelioma and hepatocellular carcinoma[1].

• UNSPSC:

  12352005

• Target:

  YAP

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Smiles:

  CC1=CC (C2=CN (C3=C2C (Cl) =NC=C3) CCO) =CC (OC4=CC=C (C=C4) C (F) (F) F) =C1

• Molecular Formula:

  C23H18ClF3N2O2

• Molecular Weight:

  446.85

• References & Citations:

  [1]Heinrich T, et al. Phenotypic Hit Identification and Optimization of Novel Pan-TEAD and Subtype-Selective Inhibitors. J Med Chem. 2025 Nov 27;68 (22) :24603-24623.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TEAD

• CAS Number:

  3074990-47-6