TEAD-IN-11

• UNSPSC Description:

  TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].

• Target Antigen:

  YAP

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tead-in-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(F)C1=CC=C(C#CC2CN(C(C=C)=O)CC2)C=C1

• Molecular Weight:

  293.28

• References & Citations:

  [1]Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3032196-88-3