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TEAD-IN-11

CAT: 0804-HY-161569-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-161569-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM) . TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1].
CAS Number
3032196-88-3
UNSPSC
12352005
Target
YAP
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tead-in-11.html
Purity
99.82
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C1=CC=C(C#CC2CN(C(C=C)=O)CC2)C=C1
Molecular Formula
C16H14F3NO
Molecular Weight
293.28
References & Citations
[1]Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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